By Daniel L. Purich
The Advances in Enzymology and comparable parts of Molecular Biology Series is among the so much prestigious within the box, dedicated to the newest traits in molecular biology and enzymology. every one quantity of the sequence comprises contributions from top professionals within the box. below Dr. Purich's editorship, which begun with quantity seventy two, the sequence has increased its assurance to incorporate thematic volumes targeting particular study parts, in addition to non-thematic volumes which includes chapters with a extra normal charm.
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Extra info for Advances in Enzymology and Related Areas of Molecular Biology, Mechanism of Enzyme Action
It should be emphasized that the uncertainty aa to the mechanism of Ct and CIaddition in no way alters the evidence (51,62) that there is such a fixation. The question is not so much whether it occurs, but how it occurs. Krebs’ (66) statement: “This (Evane and Slotin’s demonstration of fixed carbon in a-ketoglutarate) cornpletee the proof of the occurrence of reaction (9) (COOH-CO-CH, COI = COOH. COCH&OOH) in pigeon liver,” + is hardly accurate. The position of the fixed carbon in a-ketoglutarate was not known at thie time, and even now that the position of the fixed carbon is known, it can only be said that the r e d t s do not conflict with the proposed mechanism of fixation.
It is clear that there are two mechanisms for the formation of Cc dicarboxylic acids. The one is quite probably by Cc and C1 addtion and is not inhibited by malonate. The other is HETEROTROPHIC ASSIMILATION OF CARBON DIOXIDE 43 by an oxidative process, and the resulting C, dicarboxylic acids do not contain fixed carbon. This then removes one of the major criticisms of the Krebs cycle, a t least as applied to the dissimilation by liver. Much of the criticism of the Krebs cycle has centered around this point, and whether or not citrate is an intermediate.
3) from carbon dioxide by liver tissue waa the first clearly defined example of heterotrophic utilization of carbon dioxide. NHy co c:o C:NH NHr Citrulline NH, Arginine Ornithine Fig. 3. proof that carbon dioxide is fixed in urea by liver has been provided by Rittenberg and Waelsch (76) by use of Cla and by Evans and Slotin (77) with Cll. Hemingway (private communication) has demonstrated urea synthesis in vivo with mice by use of C1*. In this connection it is interesting to note that the demonstration of Ruben and Kamen (17) of fixation of carbon dioxide by liver haa been cited (53, 55) aa evidence for mechanism of carbon dioxide fixation by liver which involve a carbon to carbon linkage.
Advances in Enzymology and Related Areas of Molecular Biology, Mechanism of Enzyme Action by Daniel L. Purich