By Ashim Datta, Vineet Rakesh
Equipped round challenge fixing, this booklet lightly introduces the reader to computational simulation of biomedical shipping procedures, bridging basic conception with real-world functions. utilizing this e-book the reader will achieve a whole origin to the topic, beginning with challenge simplification, enforcing it in software program, via to reading the implications, validation, and optimization. Ten case reports, concentrating on rising components corresponding to thermal remedy and drug supply, with effortless to stick with step by step directions, supply ready-to-use templates for additional functions. answer method utilizing the generally used instrument COMSOL Multiphysics is defined intimately; valuable biomedical estate information and correlations are incorporated; and heritage thought info is given on the finish of the ebook for simple reference. a mix of brief and prolonged workouts make this booklet a whole path package deal for undergraduate and starting graduate scholars in biomedical and biochemical engineering curricula, in addition to a self-study advisor.
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Extra resources for An Introduction to Modeling of Transport Processes: Applications to Biomedical Systems
1 Which governing equations? Governing equations are statements of universal laws such as conservation of energy – they are derived in Chapter 7. An example of a set of governing equations for fluid flow, heat transfer and mass transfer in 3D in rectangular Cartesian coordinates is shown below. The symbols have their usual meanings and are shown in the List of symbols. Complete descriptions of the equations are provided in Chapter 7. Under each term in the equations below, the physical process leading to that term is noted.
Drug delivery (design of a coated tablet, design of a patch) Rate of drug release over time has to meet certain criteria such as a minimum dose; rate needs to stay near constant over time; release needs to be over a certain time period. Drug delivery (placement in tissue, as in a brain tumor) Penetration distance into the tissue (area of coverage) has to meet certain criteria. Additional criteria can be from those listed under tablet and patch. 2 What is problem formulation? , coming up with equations which describe the physical process or processes that constitute the problem (and therefore virtually replace such a process or processes).
1. 2 What is problem formulation? 1 Examples of quantitative measures of success in various biomedical processes. Process Design goal in quantitative terms Radiofrequency heating of tumorous tissue Reach temperatures in the tumorous tissue in the region of 43–45 ◦ C. Laser ablation Reach temperatures in the region to be ablated above 300 ◦ C. Cancer therapy Cumulative number of equivalent minutes of heating at 43 ◦ C, defined by Eqn. 39, needs to reach a certain value. Cryosurgery Tissue to be destroyed needs to reach below −45 ◦ C.
An Introduction to Modeling of Transport Processes: Applications to Biomedical Systems by Ashim Datta, Vineet Rakesh