Download e-book for iPad: An Introduction to Molecular Medicine and Gene Therapy by Thomas F. Kresina

By Thomas F. Kresina

ISBN-10: 0471391883

ISBN-13: 9780471391883

ISBN-10: 0471461040

ISBN-13: 9780471461043

An creation to Molecular medication and Gene treatment Edited through Thomas F. Kresina, Ph.D. Gene remedy, or using genetic manipulation for disorder remedy, is derived from advances in genetics, molecular biology, scientific medication, and human genomics. Molecular drugs, the appliance of molecular organic strategies to sickness therapy and prognosis, is derived from the improvement of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An advent to Molecular drugs and Gene remedy presents a foundation for studying new medical and easy learn findings within the components of cloning, gene move, and concentrating on; the functions of genetic drugs to scientific stipulations; ethics and governmental rules; and the burgeoning fields of genomics, biotechnology, and bioinformatics. by way of dividing the fabric into 3 sections - an creation to simple technology, a overview of medical purposes, and a dialogue of the evolving concerns with regards to gene treatment and molecular medicine-this entire handbook describes the fundamental methods to the wide diversity of exact and power genetic-based remedies. additionally, An creation to Molecular medication and Gene remedy: * Covers new frontiers in gene treatment, animal versions, vectors, gene concentrating on, and ethical/legal concerns * presents organ-based reports of present stories in gene remedy for monogenetic, multifactoral or polygenic issues, and infectious ailments * contains bold-faced phrases, key ideas, summaries, and lists of invaluable references by means of topic in every one bankruptcy * includes appendices on advertisement implications and a evaluation of the historical past of gene remedy This textbook bargains a transparent, concise writing variety, drawing upon the services of the authors, all popular researchers of their respective specialties of molecular medication. Researchers in genetics and molecular drugs will all locate An creation to Molecular drugs and Gene remedy to be a necessary advisor to the swiftly evolving box of gene remedy and its functions in molecular medication.

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Extra info for An Introduction to Molecular Medicine and Gene Therapy

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Nat Genet 23:397– 404, 1999. Gene Therapy and Aging Apfeld J, Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402:804–809, 1999. Crozier RH. Be social, live longer. Nature 389:906–907, 1997. Jazwinski SM. Longevity, genes, and aging. Science 273:54–59, 1996.

This will pave the way for medical interventions tailor-made for an individual patient (see Chapter 15). Academic medical centers can contribute to the development of personalized medicine by providing high-quality specimen banks. They can establish interactive teams of scientists and physicians who are able to conduct the complex clinical trials needed to find the best matches between the expanding universe of therapeutic options and the genetic constitution of an individual patient. GENE THERAPY AND MOLECULAR MEDICINE A simple and concise definition of gene therapy (there are many) is the use of any of a collection of approaches for the treatment of human disease that rely on the transfer of DNA-based genetic material into an individual.

But, it is estimated that only 2% of human diseases are thought to be caused by direct one-to-one Mendelian expression of a single gene. Even in these monogenetic diseases, clinical heterogeneity occurs, and it is often difficult to predict the progress of the clinical course of a patient. Patient-topatient variation results from many factors, including differences in alleles, environment, and genetic background. While the precise cause of variable penetrance of a genetic lesion is usually not known, it likely reflects the genome’s extensive series of “back-up” systems and feedback loops.

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An Introduction to Molecular Medicine and Gene Therapy by Thomas F. Kresina


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