By C.C. Reddy (Eds.)
The 1st of 2 volumes proposing present learn into oxidation structures, this booklet is meant for biochemists, toxicologists, and pharmacologists. subject matters mentioned contain the mechanisms of organic oxidations, and peroxidases in telephone defense and metabolism
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Extra info for Biological Oxidation Systems. Volume 1
Fujii-Kuriyama, Y . ( 1 9 8 3 ) / . Biochem. (Tokyo) 9 4 , 1 4 6 5 - 7 3 Biol. Chem 2 6 0 , 1 6 1 2 2 - 3 0 Biol. Chem 2 3 9 , 2 3 7 0 - 2 3 7 8 4. Omura, T. and Sato, R. (1964) /. 5. , Rosenthal, O. W. (1965) Fed. Proc. 2 4 , 1 1 8 1 - 9 (1981) Annu. Rev. Biochem. 4 9 , 3 1 5 - 5 6 6. O. J. 8. , Iizuka, T. and Fujii-Kuriyama, Y . (1983) / . Biochem 9. , Tagashira, Y . , Muramatsu, M. and 10. , (Tokyo) 9 3 , 8 0 7 - 1 7 Fujii-Kuriyama, Y . (1984) Proc. Natl. Acad. Sci. USA. R, Sato, R. R. (1987) DNA 6 , 1 - 1 1 11.
And Padmanaban, G. (1989) Proc. Natl Acad. Sci. USA 86, 3963-3967 12. , and Padmanaban, G. ( 1 9 9 0 ) / . Biol Chem, in press Oxidation Reactions Catalyzed by Cytochrome P-450 Enzymes F. Peter Guengerich Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146 USA Abstract Cytochrome P-450 ( P - 4 5 0 ) oxidations, although apparently diverse in their appearance, can be considered in terms of mechanisms involving abstraction of electrons or hydrogen atoms by hypervalent F e = 0 species and subsequent radical recombination.
Exciting results have been obtained using the expression system described ( 2 3 ) that permit the synthesis o f a single P - 4 5 0 or a combination of P-450s in cells devoid of this hemoprotein. This offers the means to establish "designer constructed" cells of predicted enzyme composition for the examination of integrated pathways o f metabolism. With the P - 4 5 0 enzymes, this approach offers the oppor tunity for developing new types of tests for toxicity evaluation o f drugs and other chemicals as well as the expression of large amounts of enzyme for commercial application to new techniques of chemistry.
Biological Oxidation Systems. Volume 1 by C.C. Reddy (Eds.)