Cancer Metastasis: Biologic Basis and Therapeutics by David Lyden, Danny R. Welch, Dr Bethan Psaila PDF

By David Lyden, Danny R. Welch, Dr Bethan Psaila

ISBN-10: 0521887216

ISBN-13: 9780521887212

Metastasis is answerable for a wide burden of morbidity and mortality between melanoma sufferers, and at present few cures particularly aim metastatic sickness. extra medical dissection of the underlying pathways is needed to pave the way in which for brand new healing ambitions. This groundbreaking new textual content comprehensively covers the techniques underlying melanoma metastasis and the scientific remedy of metastatic illness. while prior volumes were compendia of laboratory learn articles, the the world over well known authors of this quantity have summarized the state of the art learn within the metastasis box. a huge part covers the mobile and molecular pathways of metastasis and experimental suggestions and the platforms and versions utilized during this box. thus, the medical features of the main melanoma forms are thought of, targeting disease-specific learn and healing techniques to metastatic disorder. the point of interest is on novel pathophysiological insights and rising remedies; destiny instructions for learn and unmet scientific wishes also are mentioned.

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Extra resources for Cancer Metastasis: Biologic Basis and Therapeutics

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8: R16. 49. Gunther EJ et al. (2003) Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev. 17: 488. 50. Varticovski L et al. (2007) Accelerated preclinical testing using transplanted tumors from genetically engineered mouse breast cancer models. Clin Cancer Res. 13: 2168. 51. Lelekakis M et al. (1999) A novel orthotopic model of breast cancer metastasis to bone. Clin Exp Metastasis. 17: 163. 52. Al-Hajj M et al. (2003) Prospective identification of tumorigenic breast cancer cells.

Tormo D et al. (2006) Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. Am J Pathol. 169: 665. 18. Gao D et al. (2008) Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. 319: 195. 19. Liao D et al. (2007) Hypoxia-inducible factor-1a is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res. 67: 563.

68: 4500. 86. Bruns CJ et al. (1999) In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia. 1: 50. 13 87. Alves F et al. (2001) An orthotopic model of ductal adenocarcinoma of the pancreas in severe combined immunodeficient mice representing all steps of the metastatic cascade. Pancreas. 23: 227 88. Stephenson RA et al. (1992) Metastatic model for human prostate cancer using orthotopic implantation in nude mice.

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Cancer Metastasis: Biologic Basis and Therapeutics by David Lyden, Danny R. Welch, Dr Bethan Psaila

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