By R-K Li and R.D. Weisel (Eds.)
Cardiac Regeneration and service, quantity reviews using biomaterials, by myself or mixed with phone treatment, in supplying tissue-engineered constructs to fix the injured center and forestall or opposite center failure.
Part one explores the diversity of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels. additional chapters discover using biomaterials to augment stem mobile remedy for restoring ventricular functionality and producing stem cell-modified intravascular stents. half makes a speciality of tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, artificial scaffolds, phone sheet engineering, maturation of sensible cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro functions, and medical issues for cardiac tissue engineering. eventually, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
Cardiac Regeneration and service, quantity Two is complemented by means of an preliminary quantity protecting pathology and treatments. jointly, the 2 volumes of Cardiac Regeneration and service provide a entire source for clinicians, scientists, or academicians interested by cardiac regeneration, together with these drawn to mobilephone treatment, tissue engineering, or biomaterials.
- Surveys the diversity of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels.
- Focuses on tissue engineering for cardiac fix together with medical concerns for cardiac tissue engineering
- Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
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Extra info for Cardiac Regeneration and Repair. Biomaterials and Tissue Engineering
However, injection of MSCs with silanized hydoxyproypl methylcellulose did significantly improve LV end systolic diameter, fractional shortening and ejection fraction. In a mini pig MI model, Lin et al. (2010) injected bone marrow mononuclear cells (MNCs) with self-assembling oligopeptides immediately post-infarction. Injection of MNCs with peptide NFs improved MNC survival ten-fold compared with MNCs injected alone. Furthermore, injection with NFs increased MNC differentiation to endothelial and smooth muscle cells, leading to increased capillary density compared with MNC injection alone.
Loss of myocyte cell mass and subsequent replacement fibrosis causes left ventricular (LV) wall thinning and dilatation (Mann, 1999). Biomaterials and tissue-engineering-based approaches have been explored over the past decade to prevent and treat post-MI HF by attempting to replace the ECM and/or cells that are lost post-MI (Christman and Lee, 2006; Rane and Christman, 2011). , 2012). Injectable hydrogels, which are the focus of this chapter, have also been widely explored over the past decade because of their potential for minimally invasive delivery.
78:279–84. 42. Cui Y, Wei QQ, Park HK, and Lieber CM (2001). Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science. 293:1289–92. 43. Sato M, Nakajima T, Goto M, and Umezawa Y (2006). Cell-based indicator to visualize picomolar dynamics of nitric oxide release from living cells. Anal Chem. 78:8175–82. 2 Hydrogels for cardiac repair J. J. WANG and K. L. 17 Abstract: In the last decade, advancements have been made towards developing injectable hydrogels for the purpose of cardiac repair.
Cardiac Regeneration and Repair. Biomaterials and Tissue Engineering by R-K Li and R.D. Weisel (Eds.)