By Nikolai Axmacher, Björn Rasch
This edited quantity presents an outline the state of the art within the box of cognitive neuroscience of reminiscence consolidation. In a couple of sections, the editors acquire contributions of major researchers . The topical concentration lies on present problems with curiosity akin to reminiscence consolidation together with operating and long term reminiscence. specifically, the function of sleep on the subject of reminiscence consolidation may be addressed. the objective viewers essentially contains learn specialists within the box of cognitive neuroscience however the ebook can also be necessary for graduate scholars.
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For a weakly encoded memory to undergo cellular consolidation, it must be supported by de novo protein synthesis (Davis and Squire 1984). Due to the high intrinsic excitability and plasticity induced in neurons with elevated CREB function, enhancing intracellular CREB levels may similarly promote consolidation of a weakly encoded memory by artiﬁcially increasing the availability of PRPs during the post-encoding consolidation window (Barco et al. 2002). The synaptic tagging and capture hypothesis (Frey and Morris 1997, 1998) makes predictions that are consistent with these observations.
Together, these ﬁndings highlight the critical role of CREB in hippocampus-dependent memory consolidation. Similar enhancements have been Mechanisms of Memory Consolidation and Transformation 21 demonstrated in multiple brain regions in rodents, including the amygdala (Josselyn et al. 2001), insular cortex (Sano et al. 2014), and the retrosplenial cortex (Czajkowski et al. 2014). The high intrinsic excitability and plasticity induced in neurons with enhanced CREB function are thought to bias the selection of these neurons for memory encoding (Han et al.
128). This debate has dominated memory research for the past several decades, as researchers attempt to understand (1) how a memory trace forms, (2) how a memory trace changes over time, and (3) the physiological mechanisms underlying the change, or transformation, of a memory over time. Mechanisms of Memory Consolidation and Transformation 19 The process of consolidation is generally discussed in binary terms of (1) cellular (or synaptic) consolidation: rapid post-translational changes in local synapse efﬁciency and structural modiﬁcations of local neuronal networks in the hippocampus1 following memory acquisition; and (2) systems consolidation: a prolonged process following acquisition during which the memory trace reorganizes and distributes in cortical regions beyond the hippocampus (see also Chapters by Nissen and colleagues).
Cognitive Neuroscience of Memory Consolidation by Nikolai Axmacher, Björn Rasch