By Gerald P. Schatten (Eds.)
This serial offers a finished survey of the key issues within the box of developmental biology. those volumes are necessary to researchers in animal and plant improvement, in addition to to scholars and execs who wish an advent to mobile and molecular mechanisms of improvement. The sequence has lately handed its 30-year mark, making it the longest-running discussion board for modern matters in developmental biology. quantity eighty offers seven chapters at the most up-to-date examine in developmental biology.
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2003). Additionally, over the last few years, members from at least three families of morphogens, previously described for their role in controlling cell fate and tissue patterning, have been shown to act also as guidance cues: the wingless/Wnt, hedgehog (Hh), and the decapentaplegic (Dpp)/BMP/TGF‐ families. The identification of these families of guidance cues has greatly improved our understanding on the mechanisms of axon guidance and on the 29 1. Angiogenesis and Neurogenesis BMP-7 rp 1 2 5 3 4 fp Shh 1.
6. Vascular Endothelial Growth Factor Originally identified as a growth factor able to stimulate vascular permeability and EC proliferation, VEGF represents perhaps the best illustration of how the crosstalk between vessels and nerves aVects development and disease. Indeed, as described in the previous sections, VEGF is critically involved in the development and homeostasis of various tissues and organs. This is accomplished in part by its potent eVect on the vasculature, but certain novel functions of VEGF, such as those influencing morphogenesis and tissue survival, are probably independent from its ability to stimulate new vessel growth.
Angiogenesis and Neurogenesis 25 separation. Accordingly, cells with common functions are attracted to each other and cell boundaries are established between cells with diVerent properties. In that way, the identity of the many individual cell types in the complex architecture is secured and organized. , 1999). , 2002) and the separation between arterial and venous ECs in the vascular system. The hindbrain is transiently subdivided during development into repeated segments called rhombomeres. Due to expression of ephrins and Eph receptors in alternating segments (Cooke and Moens, 2002), rhombomeres are maintained as lineage‐restricted compartments.
Current Topics in Developmental Biology by Gerald P. Schatten (Eds.)