New PDF release: d-Amino Acids in Sequences of Secreted Peptides of

By P. Jolles

ISBN-10: 3034888376

ISBN-13: 9783034888370

ISBN-10: 3034897944

ISBN-13: 9783034897945

Existence on the earth nearly solely makes use of laevorotatory or left-handed amino acids (L-enantiomers), instead of D-enantiomers. however, with more advantageous analytical tools, D-amino acids were detected in quite a few peptides of multi-cellular organisms in the course of contemporary years. This publication takes inventory of our current wisdom during this speedily increasing examine sector. In a chain of chapters it discusses the characterization and research of D-amino acids, their incidence and serve as in animal peptides and proteins, a few attainable biosynthetic pathways, and their visual appeal in the course of getting older. moreover, one bankruptcy techniques the perplexing query of homochirality and lifestyles.

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FEBS Lett 355 : 96-1 00. 85. , Scaloni, A. and Segre A. (1995) Solution conformation of the Pseudomonas siringae pv syringae phytotoxic lipodepsipeptide syringopeptin 25-A. Eur J Biochem 234: 747 - 758. 86. , Pucci, P. and Scaloni, A. (1996) Structure of fuscopeptins, phytotoxic metabolites from Pseudoll1onasfuscovaginae. FEBS Lett 381 :213-216. 26 A. Scaloni et al. 87. , Simmaco, M. and Ballio, A. (1994) Stereochemical structure ofSyringomycin, a phytotoxic metabolite of Pseudomonas syringae pv syringae.

Acta Chem Scand 4:277-282. 81. , Nakashima, K. and Akiyama, S. (1995) A novel method for the amino acid sequence/configuration determination of peptides containing D/L-amino acids utilizing a fluorogenic Edman reagent, 7-N,N-dimethylaminosulphonyl-4-(2, I ,3-benzoxadiazolyl)isothiocyanate (DBD-NCS). Biomed Chromatogr9: 152-154. 82. T. A. (1987) Sequential configuration analysis of peptides. Angew Chem lnt Ed Engl4: 331-332. 83. , Simmaco, M. and Bossa, E (1991) Determination of the chirality of amino acid residues in the course of subtractive Edman degradation of peptides.

The corresponding 17-residue amidated peptide was Occurrence and function of D-amino acid-containing peptides and proteins ... 33 identified at relatively low abundance in the skin secretions by mass spectrometry. Its sequence (Fig. 2) is similar to bombinins H, but lacks the basic residues at the C-terminal extremity, which is amidated. The presence of a D-amino acid in this peptide was subsequently suggested [25]. The analysis of skin secretions from B. orientalis, performed in our laboratory, resulted in the identification of bomb in in H-type peptides similar to those found in B.

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d-Amino Acids in Sequences of Secreted Peptides of Multicellular Organisms by P. Jolles

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