New PDF release: Developmental Immunotoxicology

By Steven D. Holladay

ISBN-10: 0415284570

ISBN-13: 9780415284578

Regardless of swiftly expanding curiosity in developmental immunotoxicology, there isn't but a textbook interested in this scorching sector of analysis. Developmental Immunotoxicology fills the void with overviews of immune procedure improvement in experimental animal and human types, and discusses the complicated concerns with regards to the evolution of developmental immunology and hazard evaluate. this article describes diverse types used to check developmental immunotoxicology and examples of particular developmental immunotoxic brokers, together with therapeutics. The textual content concludes with numerous chapters that describe the position of neuroimmune interactions as they relate to developmental immunotoxicology. utilizing a didactic process, Developmental Immunotoxicology presents an explanatory assessment of this state-of-the-art box for toxicologists, immunologists, and developmental biologists. It presents a lucid account of this region of research-proposing solutions to a couple questions and stimulating debate on these questions but to be addressed via the examine group.

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DEVELOPMENT OF THE RODENT IMMUNE SYSTEM 11 vironment (Mudry et al. 2000; Banfi et al. 2001). This form of indirect hematotoxicity is intriguing and currently under investigation in a number of laboratories. The hematopoietic microenvironment is characterized by the expression of adhesion molecules and cytokines, which are both produced by stromal cells (Dorshkind, 1990; Dorshkind and Landreth 1992). Adhesion contacts with stromal cells are known to contribute to the regulation of hematopoiesis and cellular adhesion molecules fibronectin, CD44, and VCAM-1, which appear to be particularly important in this respect (Kincade et al.

1994. In vitro development of B cells and macrophages from early mouse fetal thymocytes. Eur J Immunol 24:781–784. DEVELOPMENT OF THE RODENT IMMUNE SYSTEM 19 Raff MC, Sternberg M, and Taylor RB. 1970. Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature 225:553–554. Rodewald H and Fehling HJ. 1998. Molecular and cellular events in early thymocyte development. Adv Immunol 69:1–112. Rolink A, Haasner D, Nishikawa S, and Melchers F. 1993. Changes in frequencies of clonable pre-B cells during life in different lymphoid organs of mice.

The thymic compartment responsible for positive selection of CD4+ T cells. Int Immunol 4:707–710. Cumano A, Ferraz C, Klaine M, Santo J, and Godin I. 2001. Intraembryonic, but not yolk sac hematopoietic precursors, isolated before circulation, provide long-term multilineage reconstitution. Immunity 15:477–485. Cumano A, Dieterlen-Lievre F, and Godin I. 2000. The splanchnopleura/AGM region is the prime site for the generation of multipotent hemopoietic precursors, in the mouse embryo. Vaccine 18:1621–1623.

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Developmental Immunotoxicology by Steven D. Holladay

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