Drug Device Combination Products: Delivery Technologies and - download pdf or read online

By Andrew Lewis

ISBN-10: 1845694708

ISBN-13: 9781845694708

Drug supply platforms symbolize an unlimited quarter of analysis and improvement inside of biomaterials and drugs and the call for for stylish drug supply units maintains to force novel product improvement. complex drug supply units can supply major benefits over traditional medications and units on my own, akin to elevated potency, enhanced functionality and comfort. the aim of this ebook is to demonstrate how powerful drug supply may be completed by means of ability except capsules. The e-book will supply an intensive research of the basics, functions and new applied sciences of drug-device mix items to be used during the human physique. half one offers readers with an creation and heritage to the sphere. Chapters partially speak about parts of software reminiscent of catheter established items, drug eluting stents and beads and anti-biotic loaded cements. half 3 covers the improvement of drug gadget mixture items with chapters on such themes as pre-clinical trying out, sterilisation, patent matters and legislation of drug gadget mixture items. With its individual editor and staff of overseas individuals, Drug-device mix items: supply applied sciences and purposes might be a useful reference for product improvement experts, fabrics scientists and engineers within the biomedical and academia in addition to these enthusiastic about drug supply.

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Extra resources for Drug Device Combination Products: Delivery Technologies and Applications

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Clin Orthop, 2000. 381: pp. 101±5. D. , One-stage revision of total hip arthroplasty for deep infection. Long-term followup. Clin Orthop, 1995. 321: pp. 202±7. P. , Hip prosthesis of antibiotic-loaded acrylic cement for the treatment of infections following total hip arthroplasty. J Bone Joint Surg Am, 2002. 84: pp. 123±8. A. , The outcome of two-stage arthroplasty using a custom-made interval spacer to treat the infected hip. J Arthroplasty, 1997. 12: pp. 615±23. , Peri-implant bone resorption around implants placed in alveolar bone subjected to distraction osteogenesis.

In addition to optimizing patch formulations, there are several techniques that can be applied to enhance transdermal drug delivery such as: (1) iontophoresis, which repels drug ions through the skin to the underlying tissue using a low-level electrical current [132]; (2) electroporation, which greatly increases the permeability of the cell plasma membrane as a result of short, highvoltage electrical pulses to the skin, facilitating drug transport [133, 134]; (3) ultrasonic waves that serve to disturb the skin layers; (4) microneedles that painlessly penetrate into subcutaneous tissue to enhance the drug delivery [135± 137]; and (5) photomechanical waves that disturb the skin layers (this technique is still in the early stages of development and requires further detailed studies) [138, 139].

Biodegradable materials are degraded, absorbed, and excreted by the body, and, therefore, surgical removal and bone tissue reconstruction are unnecessary. The main mechanism of polymer degradation is chemical hydrolysis. The degradation rates of these materials vary from weeks to months, so enabling treatment of different infections over various periods of 16 Drug±device combination products time. Polymers with slower degradation rates are capable of releasing drugs for longer periods, and thus may offer a more complete treatment under particular clinical infection conditions.

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Drug Device Combination Products: Delivery Technologies and Applications by Andrew Lewis


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