By Sharyn Endow, David Glover
This quantity specializes in the structural elements of telephone department, starting from nuclear envelope breakdown to cytokinesis and partitioning of the cytoplasm. It examines spindle meeting and chromosome habit in mitosis and meiosis, centromere and kinetochore constitution and legislation, telomeres, the function of centrosomes, and mechanisms through which total legislation is accomplished. Written as a spouse quantity to mobilephone Cycle keep watch over, this publication offers an updated account of advancements during this interesting zone of mobile biology.
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Extra info for Dynamics of Cell Division (Frontiers in Molecular Biology)
H. (1990) The three postblastoderm cell cycles in Drosophila are regulated in G2 by String. Cell, 62, 469. 21. , Murray, A. , and Kirschner, M. W. (1991) Cyclin is degraded by the ubiquitin pathway. Nature, 349, 132. 22. , Adamczewski, J. , and Hunt, T. (1992) Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits. Mol. Biol. Cell, 3, 1279. 23. , and Nasmyth, K. (1994) Closing the cell cycle circle in yeast-G2 cylin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.
Mutational analysis of checkpoints demonstrates that cell cycle checkpoints are essential for maintaining division fidelity in higher eukaryotes. Disruption of mammalian cell cycle checkpoints often leads to tumorigenesis. Checkpoint genes, such as p53, maintain fidelity of large populations of cells by either inducing an arrest and repair response or an apoptotic elimination response. Little is known about the environmental and genetic factors influencing which alternative is chosen. In addition, the relationship between these two responses has not been determined.
For example, it is not known whether the cell cycle arrest and apoptotic pathways are independent processes or whether they represent branchpoints of a common pathway. Given the role of cell cycle checkpoints in maintaining division fidelity in mammals, it will be important to identify those checkpoint genes that are functionally as well as structurally conserved as these are likely to be involved in core aspects of the checkpoint process. Analysis of these conserved checkpoint components in model genetic organisms will provide the most direct insight into their role in mammals.
Dynamics of Cell Division (Frontiers in Molecular Biology) by Sharyn Endow, David Glover