By Rebecca A. Bader
Polymers have performed a severe function within the rational layout and alertness of drug supply platforms that bring up the efficacy and decrease the toxicity of latest and standard therapeutics. starting with an creation to the basics of drug supply, Engineering Polymer platforms for stronger Drug Delivery explores conventional drug supply strategies in addition to rising complex drug supply innovations. by means of reviewing many varieties of polymeric drug supply structures, and together with key issues, labored examples and homework difficulties, this e-book will function a consultant to for experts and non-specialists in addition to a graduate point textual content for drug supply courses.
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No direct change is made to the transport protein in this process. These proteins are 38 CHALLENGES OF DRUG DELIVERY structurally selective for the drugs that they transport and are saturable. Thus, the maximum rate of absorption will be dependent on the concentration of receptor, not on the concentration of the drug . Channel-mediated diffusion requires continuous aqueous pores spanning a lipid bilayer membrane. Charged or polar drugs are able to travel through these channels faster than by passive diffusion through the membrane; therefore, the rate of drug absorption is increased .
P 247. 35. Welty JR. Fundamentals of Momentum, Heat, and Mass Transfer. 4th ed. New York: Wiley xii; 2001. p 759. 36. Cussler EL. Diffusion: Mass Transfer in Fluid Systems. 2nd ed. New York: Cambridge University Press xviii; 1997. p 580. 37. Bird RB, Stewart WE, Lightfoot EN. Transport Phenomena. 2nd, Wiley international ed. New York: John Wiley & Sons, Inc. xii; 2002. p 895. 38. Crank J. The Mathematics of Diffusion. 2d ed. Oxford, England: Clarendon Press viii; 1975. p 414. 39. Bader RA, Kao WJ.
Though vital for normal function, the liver provides an undeniable barrier to drug delivery. Drug molecules with structural or chemical properties similar to those of the natural liver substrates will be metabolized in the liver via the same metabolic pathways. , the glyceryl trinitrate, used to treat angina, and lidocaine, an analgesic) are rendered useless when delivered orally because of extensive metabolism by the liver . The cytochrome P450 (CYP) enzyme family is the major source of enzyme activity involved in hepatic metabolism.
Engineering Polymer Systems for Improved Drug Delivery by Rebecca A. Bader