By Roger G. Melton, Richard J. Knox
Antibody-directed enzyme prodrug treatment (ADEPT) without delay addresses the foremost challenge in melanoma chemotherapy-its loss of selectivity. Antibody supply mixed with the amplification supplied via the enzymatic activation of prodrugs allows choice to be made among tumour and basic tissue. ADEPT deals a singular box of possibilities within the treatment of systemic melanoma and should be an incredible enhance for the therapy of reliable tumours.
This ebook is the 1st to explain ADEPT intimately. each one bankruptcy stories a side of the immunology, enzymology, biochemistry, chemistry, and melanoma chemotherapy that have been built-in into the ADEPT proposal. an extra bankruptcy describes the similar process of gene-directed enzyme prodrug treatment (GDEPT). This latter procedure remains to be in its infancy yet ADEPT has entered the health facility. The preliminary medical stories with ADEPT are integrated and mentioned in detail.
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Extra resources for Enzyme-Prodrug Strategies for Cancer Therapy
It is now recognized that the physiology of tumors offers opportunities and obstacles to antibody-based therapy, quite apart from any considerations relating to the nature and distribution of the target antigen, which are discussed in the latter part of this chapter. 2. Route of Administration The route by which an antibody-enzyme conjugate is administered has significant implications for its biodistribution. The most common method of administration is by intravenous injection as a bolus or as a prolonged infusion.
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Enzyme-Prodrug Strategies for Cancer Therapy by Roger G. Melton, Richard J. Knox