Download PDF by Anthony Atala, James J Yoo: Essentials of 3D Biofabrication and Translation

By Anthony Atala, James J Yoo

ISBN-10: 0128009721

ISBN-13: 9780128009727

ISBN-10: 0128010150

ISBN-13: 9780128010150

Essentials of 3D Biofabrication and Translation discusses the concepts which are making bioprinting a practicable replacement in regenerative drugs.

The e-book runs the gamut of subject matters concerning the topic, together with hydrogels and polymers, nanotechnology, toxicity trying out, and drug screening systems, additionally introducing present functions within the cardiac, skeletal, and frightened structures, and organ development.

Leaders in scientific drugs and translational technological know-how supply an international point of view of the transformative nature of this box, together with using cells, biomaterials, and macromolecules to create easy development blocks of tissues and organs, all of that are riding the sector of biofabrication to remodel regenerative medicine.

  • Provides a brand new and flexible approach to fabricating dwelling tissue
  • Discusses destiny purposes for 3D bioprinting applied sciences, together with use within the cardiac, skeletal, and apprehensive structures, and organ construction
  • Describes present methods and destiny demanding situations for translational science
  • Runs the gamut of subject matters with regards to the topic, from hydrogels and polymers to nanotechnology, toxicity checking out, and drug screening platforms

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Additional resources for Essentials of 3D Biofabrication and Translation

Sample text

These software tools support typical biomedical workflows that usually start with the acquisition of patient images and the conversion of these images into a high-quality digital 3D model. This 3D model is the starting point for all further operations and is crucial to the overall process quality, for example, the design of a patient-specific implant. The creation of the physical device by additive manufacturing, commonly called 3D printing, requires dedicated software to preprocess the design and optimize it for the printing process of choice.

By building the part vertically, the part quality will be optimized with a significant reduction in necessary support structure at the cost of increased build time. Essential to any AM software is an orientation optimizer as well as an automatic support generator with manual editing capabilities. 4 Build Processor As mentioned earlier, STL files only contain geometrical part information and thus build instructions, such as material composition, slicing strategy, and hatching strategies, must be provided to successfully print a part.

Metal parts need supports to be anchored to the platform as well, although not to prevent unnecessary translation but to prevent warping due to thermal stresses. Supports for metal parts also have a critical function as heat sinks to provide thermal dissipation. When a CAD model is placed on an AM machine platform, part orientation must be considered to optimize the quality of a part and build speed and the amount of required support structure. For example, building a cylindrical rod lengthwise horizontally will maximize build speed but sacrifice part quality (build layers are visible on the part and require extra finishing and increase the amount of support structure needed to successfully build the part).

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Essentials of 3D Biofabrication and Translation by Anthony Atala, James J Yoo

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