Download e-book for iPad: Gene therapy: Potential applications of nanotechnology by Surendra Nimesh

By Surendra Nimesh

ISBN-10: 1907568409

ISBN-13: 9781907568404

Gene remedy is rising as a brand new type of therapeutics for the remedy of inherited and purchased illnesses. despite the fact that, bad mobile uptake and instability of DNA within the physiological milieu limits its healing capability. Nanotechnology dependent non viral vectors were proposed as strength applicants to successfully delivery DNA to the objective cells. quite a few polymeric nanoparticles were proven to be appropriate, with excessive mobile uptake efficiencies and lowered cytotoxicity. Dr. Surendra Nimesh supplies a scientific account of the various elements of nanotechnology-mediated gene remedy, from the instruction of nanoparticles to physicochemical characterization, and follows with purposes in in vitro and in vivo types. within the concluding chapters he presents exhaustive info on polymeric platforms hired for gene therapy.

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1990) Kinetics of emulsifier-free emulsion polymerization of styrene. J Polym Sci Part A Polym Chem, 28, 2359–92. 11. , Sun, L. et al. (1992) Model filled polymers V. Synthesis of crosslinked monodisperse polymethacrylate beads. J Polym Sci Part A Polym Chem, 30, 137–44. 12. A. and Rudin, A. (1994) Practical aspects of the emulsifier-free emulsion polymerization of styrene. Eur Polym J, 30, 179–83. 13. S. H. (2002) Effects of charge density and particle size of poly[styrene/(dimethylamino)ethyl methacrylate] nanoparticle for gene delivery in 293 cells.

1996) Effect of PEO surface density on long-circulating PLA-PEO nanoparticles which are very low complement activators. Biomaterials, 17, 1575–81. 5. Birrenbach, G. P. (1976) Polymerized micelles and their use as adjuvants in immunology. J Pharm Sci, 65, 1763–6. 6. , Gonczol, E. et al. (1994) Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci U S A, 91, 4407–11. 7. , Margalit, R. et al. (2007) Nanocarriers as an 11 Published by Woodhead Publishing Limited, 2013 Gene therapy emerging platform for cancer therapy.

The nanocapsule suspension was then concentrated under reduced pressure. Although there was twice as much surfactant as polymer in the raw suspension, no purification was described. A significant amount of effort has been made to entrap hydrophilic drug in the nanoparticles prepared by interfacial polymerization. El Samaligy et al. 29 The successful entrapment of doxorubicin was demonstrated by this procedure. The aqueous solution was emulsified in an organic phase (cyclohexane or chloroform) containing a surfactant to which the monomer was added.

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Gene therapy: Potential applications of nanotechnology by Surendra Nimesh


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