New PDF release: RNA Nanotechnology

By Bin Wang

ISBN-10: 9814411647

ISBN-13: 9789814411646

ISBN-10: 9814411655

ISBN-13: 9789814411653

In the previous few many years there was exceptional progress in "bionano"-related learn, which has been observed via quite a few courses during this box. even supposing quite a few compilations handle issues on the topic of deoxyribonucleic acid (DNA) and protein, there are few books that target making a choice on the constitution of ribonucleic acid (RNA) and utilizing RNA as development blocks to build nanoarchitectures for biomedical and healthcare applications.

RNA Nanotechnology is a finished quantity that information either the normal techniques and the most recent advancements within the box of RNA-related expertise. This e-book pursuits a large viewers: a wide creation presents a pretty good educational historical past for college kids, researchers, and scientists who're strange with the topic, whereas the in-depth descriptions and discussions are valuable for complicated execs.

The publication opens with reports at the easy features of RNA biology, computational ways for predicting RNA buildings, and standard and rising experimental methods for probing RNA constructions. This part is through explorations of the most recent examine and discoveries in RNA nanotechnology, together with the layout and building of RNA-based nanostructures. the ultimate phase of the publication comprises descriptions and discussions of the capability organic and healing functions of small RNA molecules, comparable to small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.

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Sample text

The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell, 71, 527–542. 10. , et al. (1996). Crystal structure of a group I ribozyme domain: principles of RNA packing. Science, 273, 1678–1685. 11. , et al. (2004). Building programmable jigsaw puzzles with RNA. Science, 306, 2068–2072. 12. F. (2006). The crystal structure of tRNA. J. , 31, 453–457. 13. E. (1998). RNA structure. Curr. Opin. Struct. , 8, 278–285.

The strategies for the formation of complexes employ to various degrees hydrogen bonding, stacking of aromatic residues, and recognition of intricate complementary surfaces. By applying the lessons learned from the structures of naturally occurring RNPs, nanotechnology has incorporated proteins into the design of structures that appear to form more readily than when using only RNA as building blocks [51]. 2 Drugs Targeting RNA Small molecules that bind to the naturally occurring RNAs either prevent the binding of an important macromolecule (protein or RNA), distort the RNA’s active conformation, or bind in competition with a cofactor.

46. , et al. (2006). Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. , 2, e62. 47. , et al. (2009). 0: databases to support mining and annotation of functional RNAs. , 37, D89–D92. 48. , et al. (2008). Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat. Methods, 5, 621–628. 49. , et al. (1997). A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. III. The topography of the functional center. J. Mol. , 271, 566–587. 50.

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RNA Nanotechnology by Bin Wang


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