By Rodrigo T Calado
This distinctive quantity of Progress in Molecular Biology and Translational Science makes a speciality of telomeres in healthiness and illness. This quantity covers a number of subject matters with studies written by way of specialists within the field.
- Contributions from experts in telomere ailments
- Informs and updates on how telomere disorder can cause sickness in humans
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2007;318:798–801. 35. Cusanelli E, Romero CA, Chartrand P. Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres. Mol Cell. 2013;51:780–791. 36. Cesare AJ, Hayashi MT, Crabbe L, Karlseder J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 2013;51:141–155. Telomeres and Telomerase 31 37. Jacobs JJ. Loss of telomere protection: consequences and opportunities. Front Oncol. 2013;3:88.
Telomeres: guardians of genomic integrity or double agents of evolution? In: Nosek J, Toma´ska L, eds. Origin and Evolution of Telomeres. Landes: Bioscience; 2008:100–108. CHAPTER TWO Human Telomeres and Telomere Biology Disorders Sharon A. Savage Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Contents 1. Introduction 2. 4 Measuring TL 3. What Is a TBD? 4. 8 Genetic anticipation 5. Germ-Line Genetics of TBDs 6. Diagnosing TBDs 7.
Mitchell JR, Cheng J, Collins K. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3’ end. Mol Cell Biol. 1999;19:567–576. 115. Lin J, Ly H, Hussain A, et al. A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. Proc Natl Acad Sci USA. 2004;101:14713–14718. 116. Chen JL, Opperman KK, Greider CW. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res.
Telomeres in health and disease by Rodrigo T Calado