By David Feldman; Francis H Glorieux; J Wesley Pike
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Extra resources for Vitamin-Binding Proteins: Functional Consequences
Hessel, A. Isken, et al. 2005. Towards a Better Understanding of Carotenoid Metabolism in Animals. Biochem Biophys Acta 1740, no 2: 122–31. , H. Escriva, S. C. Zhang, and V. Laudet. 2006. Conserved Rare Localization in Amphioxus Hox Clusters and Implications for Hox Code Evolution in the Vertebrate Neural Crest. Dev Dynam 235, no 6: 1522–31. Wang, Z. , P. Dollé, W. V. Cardoso, and K. Niederreither. 2006. Retinoic Acid Regulates Morphogenesis and Patterning of Posterior Foregut Derivatives. Dev Biol 297, no 2: 433–45.
Collectively, these data suggest that in the course of metazoan evolution the functions for retinoids might have originated before a functional RXR/RAR heterodimer and that the presence of both RAR and RXR in a genome does not automatically imply a functional RXR/RAR heterodimer capable of binding and being activated by retinoids. 7 CONCLUSION Considerable time and effort have been invested by the scientific community in the analysis of metabolism and functions of RA during development. It is clear that the signaling cascade controlled by this morphogen intervenes in various tissues at different time points during embryogenesis.
Development 126, no 11: 2539–50. Osborne, P. , G. Benoit, V. Laudet, M. Schubert, and D. E. K. Ferrier. 2009. Differential Regulation of Parahox Genes by Retinoic Acid in the Invertebrate Chordate Amphioxus (Branchiostoma floridae). Dev Biol 327, no 1: 252–62. , J. Farrés, N. Kedishvili, and G. Duester. 2008. Medium-Chain and Short-Chain Dehydrogenases/Reductases in Retinoid Metabolism. Cell Mol Life Sci 65, no 24: 3936–49. , N. J. Brand, A. Krust, and P. Chambon. 1987. A Human Retinoic Acid Receptor Which Belongs to the Family of Nuclear Receptors.
Vitamin-Binding Proteins: Functional Consequences by David Feldman; Francis H Glorieux; J Wesley Pike